A 2020 case study examined five adults who had experienced signs of hepatotoxicity, or toxicity to the liver, after using ashwagandha in varying doses. Dasgupta A, Tso G, Wells A. This means not enough is known about either the safety or effectiveness of taking daily ashwagandha for an extended period of time. The average vitamin or mineral should not affect your antidepressant's functionality or your health. However, many studies supporting the use of ashwagandha are small or poorly designed. This information does not endorse any treatments or medications as safe, effective, or approved for treating a . View abstract. Monitor your blood pressure closely. doi:10.1097/MD.0000000000017186, Pratte MA, Nanavati KB, Young V, Morley CP. Ashwagandha might cause sleepiness and drowsiness. View abstract. It should not be confused with Physalis alkekengi, which is also referred to as winter cherry. Cancer Lett 2000;148:9-17. 2011;68(1):3-8. Phytother Res 2022. I recommend taking it at bedtime for a better night's rest or you can take it during the day. Twelve studies were included in the final review, and researchers concluded that ashwagandha showed more improvements in physical performance than placebo pills. Ashwagandha might increase how much thyroid hormone the body produces. Does Ashwagandha Interact With Any Medications? Dosage: How Much Ashwagandha Should I Take? Indian J Physiol Pharmacol. One study, published in Phytotherapy Research, reported that ashwagandha supplementation reduced blood sugar and A1c levels, although this was a relatively small study. 4. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. 2019;11(9):e5797. Ashwagandha can also interact with some medications and affect how they work. Critical review of theWithania somnifera(L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa. This includes: As with many other herbs and supplements, ashwagandha has a risk of side effects. 2009;15(4):423-430. View abstract. Thank you, {{form.email}}, for signing up. 2020;34(5):1041-1059. First and foremost, I want to point out this it can tricky to determine whether or not a dietary/herbal supplement will interact with prescription drugs due to a general lack of studies on the matter. Thyroid Suppression Test. Sleep Med. By Brittany Lubeck, RD Commonly prescribed SSRIs include sertraline (brand name Zoloft), paroxetine (Paxil), fluoxetine (Prozac) and citalopram (Celexa). It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. Ashwagandha has also been used to increase performance among athletes and improve male infertility. Sedatives: Since ashwagandha can both energize and induce restorative sleep, it might negate or amplify the effect of other sedative drugs, especially the benzodiazepines. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. Phytomedicine 2000;7(6):463-469. View abstract. Curr Clin Pharmacol. View abstract. The herb has been proven to interact with many other drugs, the interaction with SSRI (selective serotonin reuptake inhibitor) or Benzodiazepines are not proven scientifically. Those who took 600 milligrams per day of ashwagandha had better results than those in the 250 milligrams per day group, yet both groups saw improvements in stress. Kumar S, Bouic PJ, Rosenkranz B. Some research shows that ashwagandha may provide benefits for stress, anxiety, memory loss, insomnia, and other health conditions. Consult a doctor before taking any medication. Essential vitamins, minerals and amino acids that are involved in neurobiological function include: However, several of these have had mixed results in helping support depression treatment. Cureus 2022;14(10):e30433. 2020;40(4):825-829. doi:10.1111/liv.14393, Siddiqui S, Ahmed N, Goswami M, Chakrabarty A, Chowdhury G. DNA damage by withanone as a potential cause of liver toxicity observed for herbal products ofWithania somnifera(ashwagandha). ashwaganda: Dosing, contraindications, side effects, and pill pictures - epocrates online Drug Lookup: Browse: Drugs Alt Meds Select a medication above to begin. Memorial Sloan-Kettering Cancer Center: Ashwagandha, NYU Langone Medical Center: Ashwagandha Interactions You Should Know About, NYU Langone Medical Center: Benzodiazepines, "Therapeutic Drug Monitoring"; Herbal Supplements and Therapeutic Drug Monitoring; A. Dasgupta; April 2008, University of Maryland Medical Center: Anaphylaxis. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. However, tyramine-rich foods like cheeses, beer and other fermented products are dangerous for people taking MAOIs. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Indian J Exp Biol 1997;35:236-9. For more information, read the "What else do I need to know?" section below. A total of 203 drugs are known to interact with levothyroxine . Feel free to send him an email at Hello@HelloPharmacist.com! View abstract. A systematic review and meta-analysis of randomized controlled trials. Due to an overall lack of scientific evidence, there are no standard dosage guidelines for ashwagandha. Examples of immunosuppressants include azathioprine, cyclosporine, mycophenolate, prednisone and corticosteroids. Hypothyroidism, After Thyroid Removal. View abstract. Anbalagan K and Sadique J. Withania somnifera (ashwagandha), a rejuvenating herbal drug which controls alpha-2 macroglobulin synthesis during inflammation. 2017 Jan;22(1):96-106 View abstract. Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Consult your doctor before taking ashwagandha if you use digoxin. Taking ashwagandha along with diabetes medications might cause blood sugar to drop too low. Additionally, a pilot study looked at ashwagandha's effects on people with mild cognitive impairment. 2017;10(3):96-100. doi:10.5935/1984-0063.20170018. Curr Sports Med Rep. 2017;16(4):230-239. doi:10.1249/JSR.0000000000000385. Front Pharmacol 2022;13:901710. lisinopril, captopril, benazepril, quinapril), ARBs (e.g. If you're taking antidepressants and vitamins at the same time, be aware of the ingredients in your vitamin supplements. In 2020 and 2021, some people began using ashwagandha to diminish the harmful effects of COVID-19, although there is no evidence to support that use. It was concluded that participants from all five studies found improvements in their anxiety. The Journal of Psychiatry study reported that omega-3 fats and vitamin D are the two essential nutrients that are most likely to help reduce depression symptoms. If you take a drug meant to suppress your immune systems, such as methotrexate or mycophenolate, they may have conflicting effects. Although, it's important to note that long-term studies have not been performed on ashwagandha. These supplements may contain similar active ingredients or have potential uses that are like those of ashwagandha. Some of these interactions can be life-threatening. Is it safe to take ashwagandha every day? The specific components of physical performance included strength and power, endurance, and fatigue/recovery. In Ayurvedic medicine, ashwagandha has been used for centuries as an alternative treatment for anxiety. Hence, be cautious if taking these medications and want to take Ashwagandha also. The liver damage never progressed to liver failure, and most cases were resolved within five months. Its scientific name is Withania somnifera Dunal, and it belongs to a class of herbs called rasayana, praised for their revitalizing effects on health. 2003;19(3):211-222. Ashwagandha and other dietary supplements should never replace standard medicine or care. https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. After 60 days, participants who took ashwagandha reported lower levels of stress and were also found to have reduced cortisol levels. Naturopathic care for anxiety: a randomized controlled trial ISRC TN78958974. Take extra care driving and doing tasks that you need to be alert for while taking this product. Take extra care and check with your doctor if you have: Signs of a very bad reaction. View abstract. You will need to talk about the benefits and risks of using this natural product. We comply with the HONcode standard for trustworthy health information. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Some medications, called sedatives, can also cause sleepiness and slowed breathing. View abstract. It may also interact with medications for these conditions. Akhgarjand C, Asoudeh F, Bagheri A, et al. View abstract. Ashwagandha may interact with various medications. Diarrhea. View abstract. Indian J Pharmacol. View abstract. 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. When possible, choose a supplement tested by a trusted third party, such as U.S. Pharmacopeia (USP), ConsumerLab, or NSF. 2021;272:113929. doi:10.1016/j.jep.2021.113929, Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. It's best to talk to your doctor before you start taking antidepressants and vitamins, especially mixed supplements. She founded the Fad Free Nutrition Blog and Nutricion al Grano websites and is based in Texas. View abstract. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. Mixing tyramine and MAOI antidepressants can result in headache, nausea, anxiety, dangerously high blood pressure and even hemorrhagic stroke. Curr Res Toxicol. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. In this randomized, double-blind, placebo-controlled trial, 125 adult participants were randomized to either 300 milligrams per day of ashwagandha sustained release or a placebo for 90 days. If you have blood sugar problems, keep hard candies, glucose tablets, liquid glucose, or juice on hand for low blood sugar.
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